Effect of Para-amino-salicylic Acid on Prothrombin Time

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Clinical trial of para-amino-salicylic acid in the treatment of rheumatoid arthritis.

Para-amino-salicylic acid (PAS) has been used in recent years in the treatment of pulmonary tuberculosis. A review of some of the relevant literature has recently been given by Joules and Nassau (1949). Its action is believed to depend upon its close physico-chemical relationship to other substances taking part in the respiratory processes of the tubercle bacillus (Bernheim, 1940). Its pharmaco...

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Amino acid composition of human plasma prothrombin.

The amino acid composition of purified human plasma prothrombin was determined by ion exchange chromatography. In some cases, the carbohydrate composition was also estimated. Seven preparations, isolated in two different laboratories and finally purified by two different methods, were studied. Within experimental error, all the preparations had the same amino acid composition, which was as foll...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1950

ISSN: 0021-9746

DOI: 10.1136/jcp.3.2.114